Research Institute for 

Pharmacy & Biochemistry

cs-CZen-GB
16 November 2019
Course description

Bioavailability and biorelevant dissolution

The lecturers use their rich experience gained when solving real problems in the pharmaceutical R&D. In the introduction bioavailability of drugs and its optimization, i.e. modification of physico-chemical properties of a drug molecule in the chemical and formulation context, are considered. Advantages, disadvantages and application of individual pharmacopoeial dissolution methods that are used primarily in quality control are discussed in details.

The key part of the course is the problematics of so-called dynamic biorelevant dissolution, i.e. methods that provide results of formulation evaluation comparable with in-vivo studies. Simulation using dynamic biorelevant dissolution improves dissolution evaluation of oral drug formulations and increases the prediction value of dissolution. Using this approach, the number of unsuccessful bioequivalence studies can be minimized, and an appropriate formulation can be proposed. The review of existing dissolution systems and information how to stimulate physiological conditions of human gastro-intestinal tract for particular types of oral formulations to obtain the most objective results are provided. Also influence of food and interactions between drugs and excipients are mentioned. Examples of interactions between drugs administered in fixed combinations that influence bioequivalence are given.

The leader of the course is Dr. Dionigio Franchi, the former Director and Site Lead of the Pharmaceutical Development Department in the R&D of the original pharmaceutical company GlaxoSmithKline, Verona. His professional experience is the guarantee of the course quality. His lectures are in English, therefore course participants should understand English. Other lecturers are Natalia CsókováMartin Čulen and Josef Jampilek.

More details

Date: in the plan

The next earliest date:

Location: Brno

Course price: 

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If you are interested in this course please contact us by e-mail on info@vufb.eu. Thank you.

The course price is payable in advance based on a proforma invoice, which is sent electronically. The fee is to be paid within 10 days after receipt of the proforma invoice. Otherwise the booking will be released to another party. After receipt of the amount to our account your participation in the course is guaranteed.

Number of participants is limited.

After completion of the course each participant will receive a certificate verifying completion of the course.

For more details please see General Terms and Conditions of Training Organized by VUFB in the Czech Republic.

Terms and conditions for in-house courses will be agreed individually.