Research Institute for 

Pharmacy & Biochemistry

25 May 2019
Lecturer profile

Assoc. Prof. Josef Jampílek, Ph.D.

Assoc. Prof. Josef Jampílek graduated from the Faculty of Pharmacy of the Charles University in Hradec Kralove and defended his doctoral thesis in Medicinal Chemistry there in 2004. After completion of his studies Josef Jampilek started working in the R&D Division of the pharmaceutical company Zentiva, Czech Republic, where he held different expert and managerial posts until 2011. In Zentiva he got valuable experience. From 2006 he also works at the Department of Chemical Drugs at the Faculty of Pharmacy of the University of Veterinary and Pharmaceutical Sciences in Brno, Czech Republic, where he defended his Associate Professor thesis in Medicinal Chemistry in 2009.

Mr. Jampílek deepened his professional knowledge during research fellowship at the Medicinal Chemistry Institute of the Heidelberg University, Germany, and at multiple specialized courses in the field of organic and analytical chemistry, clinical drug trial, quality control/quality assurance, GxP for R&D of drugs, etc. He developed and improved his managerial skills within the long-term training programme and at a number of short-term courses.

In 2000 to 2003 he was a co-executor of the project "Research Centre of Structure and Mechanism of Action of Potential Drugs" established by the Ministry of Education of the Czech Republic at the Faculty of Pharmacy of Charles University in close cooperation with the Research Institute for Pharmacy and Biochemistry (VUFB) and the pharmaceutical company Léčiva (both Prague, Czech Republic). At present Mr. Jampílek participates in joint research projects with colleagues from different Czech universities and the Academy of Sciences of Czech Republic and closely cooperates with scientists from, for example, the University of Sydney, Australia; the Cork Institute of Technology, Ireland; the Faculty of Natural Sciences of the Comenius University, Slovakia; and the Institute of Chemistry of the University of Silesia, Katowice, Poland. In the last mentioned university he also teaches Drug Design as a visiting professor. At the Faculty of Pharmacy of the University of Veterinary and Pharmaceutical Sciences Brno he is the guarantor of the course "Molecular Principles of Drug Design".

The areas of his scientific interest include design, synthesis and structure-activity relationships of heterocyclic compounds as potential drugs and potential photosynthesis inhibitors. He is also interested in ADME problematics and drug bioavailability, physico-chemical properties of potential drugs, potential transdermal penetration enhancers, nanoparticles and modern methods of pharmaceutical analysis, especially solid-state analysis.

For his scientific results Mr. Jampílek earned several awards, for example, "Prix de Pharmacie 2004" of Aventis and, as a member of teams, "Most Cited Paper 2006 – 2009 Award" granted by the journal Bioorganic & Medicinal Chemistry, Elsevier and "2011 Industrial Affairs Innovation Award" granted by Sanofi.

He is a member of scientific and professional societies and councils, a guest editor of Current Pharmaceutical Design and Current Organic Chemistry and an external project evaluator of different grant agencies.

He is an author/co-author of 20 patent applications, 60 scientific publications, more than 120 conference contributions, 6 university textbooks and 7 chapters in monographs.

Selected publications:

Jampílek, J.; Doležal, M.; Kuneš, J.; Víchová, P.; Jun, D.; Hanika, J.; O´Connor, R.; Clynes, M. Synthesis of (2E)-2-Methyl-3-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)prop-2-enoic Acid (VUFB 20609) and 2-Methyl-3-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)propionic Acid (VUFB 20584) as Potential Antileukotrienic Agents. J. Pharm. Pharmacol. 2004, 56 (6): 783–794.

Jampílek, J.; Doležal, M.; Kuneš, J.; Víchová, P.; Jun, D.; Raich, I.; O´Connor, R.; Clynes, M. Preparation of 2-(4-{[4-(Quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)propionic Acid (VUFB 20615) and 2-Methyl-2-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)propionic Acid (VUFB 20623) as Potential Antileukotrienic Agents. Curr. Org. Chem. 2004, 8 (13): 1235–1243.

Jampílek, J.; Doležal, M.; Kuneš, J.; Šatínský, D.; Raich, I. Novel Regioselective Preparation of 5-Chloropyrazine-2-carbonitrile from Pyrazine-2-carboxamide and Coupling Study of Substituted Phenylsulfanylpyrazine-2-carboxylic Acid Derivatives. Curr. Org. Chem. 2005, 9 (1): 49–60.

Jampílek, J.; Doležal, M.; Opletalová, V.; Hartl, J. 5-Lipoxygenase, Leukotrienes Biosynthesis and Potential Antileukotrienic Agents. Curr. Med. Chem. 2006, 13 (2): 117–129.

Musioł, R.; Jampílek, J.; Buchta, V.; Silva, L.; Niedbala, H.; Podeszwa, B.; Pałka, A.; Majerz-Maniecka, K.; Oleksyn, B.; Polański, J. Antifungal Properties of New Series of Quinoline Derivatives. Bioorg. Med. Chem. 2006, 14 (10): 3592–3598.

Vinšová, J.; Čermáková, K.; Tomečková, A.; Čečková, M.; Jampílek, J.; Čermák, P.; Kuneš, J.; Doležal, M.; Štaud, F. Synthesis and Antimicrobial Evaluation of New 2-Substituted 5,7-Di-tert-butylbenzoxazoles. Bioorg. Med. Chem. 2006, 14 (17): 5850–5865.

Musioł, R.; Jampílek, J.; Kráľová, K.; Richardson, D.R.; Kalinowski, D.; Podeszwa, B.; Finster, J.; Niedbala, H.; Pałka, A.; Polański, J. Investigating Biological Activity Spectrum for Novel Quinoline Analogues. Bioorg. Med. Chem. 2007, 15 (3): 1280–1288.

Imramovský, A.; Polanc, S.; Vinšová, J.; Kočevar, M.; Jampílek, J.; Rečková, Z.; Kaustová, J. A New Modification of Antitubercular Active Molecules. Bioorg. Med. Chem. 2007, 15 (7): 2551–2559.

Vinšová, J.; Imramovský, A.; Jampílek, J.; Monreal-Férriz, J.; Doležal, M. Recent Advances on Isoniazide Derivatives. Anti-Infective Agents Med. Chem. 2008, 7 (1): 12–31.

Musioł, R.; Tabak, D.; Niedbala, H.; Podeszwa, B.; Jampílek, J.; Kráľová, K.; Dohnal, J.; Finster, J.; Mencel, A.; Polański, J. Investigating Biological Activity Spectrum for Novel Quinoline Analogues 2: Hydroxyquinolinecarboxamides with Photosynthesis Inhibiting Activity. Bioorg. Med. Chem. 2008, 16 (8): 4490–4499.

Doležal, M.; Čmedlová, P.; Palek, L.; Vinšová, J.; Kuneš, J.; Buchta, V.; Jampílek, J.; Kráľová, K. Synthesis and Antimycobacterial Evaluation of Substituted Pyrazinecarboxamides. Eur. J. Med. Chem. 2008, 43 (5): 1105-1113.

Opletalová, V.; Kalinowski, D.; Vejsová, M.; Kuneš, J.; Pour, M.; Jampílek, J.; Buchta, V.; Richardson, D.R. Identification and Characterization of Thiosemicarbazones with Anti-Fungal and Anti-Tumor Effects: Cellular Iron-Chelation Mediating Cytotoxic Activity. Chem. Res. Toxicol. 2008, 21 (9): 1878–1889.

Imramovský, A.; Vinšová, J.; Monreal-Férriz, J.; Buchta, V.; Jampílek, J. Salicylanilide Esters of N-Protected Amino Acids as Novel Antimicrobial Agents. Bioorg. Med. Chem. Lett. 2009, 19 (2): 348–351.

Imramovský, A.; Vinšová, J.; Monreal-Férriz, J.; Doležal, R.; Jampílek, J.; Kaustová, J.; Kunc, F. New Antituberculotics Originated from Salicylanilides with Promising In Vitro Activity against Atypical Mycobacterial Strains. Bioorg. Med. Chem. 2009, 17 (10): 3572–3579.

Brychtová, K.; Opatřilová, R.; Raich, I.; Kalinowski, D.; Dvořáková, L.; Plaček, L.; Csőllei, J.; Richardson, D.R.; Jampílek, J. Investigating the Activity of 2-Substituted Alkyl-6-(2,5-dioxopyrrolidin-1-yl)hexanoates as Skin Penetration Enhancers. Bioorg. Med. Chem. 2010, 18 (24): 8556-8565.

Modern Approaches to Pharmaceutical Analysis. Jiří Dohnal, Josef Jampílek, Vladimír Král, Anna Řezáčová (Eds.). Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Prague, 2010. [Printed: ISBN 978-80-7305-085-6, CD-Edition: ISBN 978-80-7305-095-5]

Mrózek, L.; Dvořáková, L.; Mandelová, Z.; Rárová, L.; Řezáčová, A.; Plaček, L.; Opatřilová, R.; Dohnal, J.; Paleta, O.; Král, V.; Drašar, P.; Jampílek, J. Investigation of New Acyloxy Derivatives of Cholic Acid and Their Esters as Drug Absorption Modifiers. Steroids 2011, 76 (10-11): 1082-1097.

Brychtová, K.; Dvořáková, L.; Opatřilová, R.; Raich, I.; Káčerová, S.; Plaček, L.; Kalinowski, D.; Richardson, D.R.; Jampílek, J. Investigation of Substituted 6-Aminohexanoates as Skin Penetration Enhancers. Bioorg. Med. Chem. 2012, 20 (1): 86–95.

Jampílek, J.; Brychtová, K. Azone Analogues: Classification, Design, and Transdermal Penetration Principles. Med. Res. Rev., in press, DOI 10.1002/med.20227.

Doležal, M.; Zitko, J.; Jampílek, J. Pyrazinecarboxylic Acid Derivatives with Antimycobacterial Activity. In: Understanding Tuberculosis – New Approaches to Fighting Against Drug Resistance. Pere-Joan Cardona (Ed.). InTech, Rijeka, Croatia, 2012, Chapter 10, p. 233-262. [ISBN 978-953-307-948-6]