Research Institute for 

Pharmacy & Biochemistry

25 May 2019
Lecturer profile

Lukáš Plaček, Ph.D.

Mr. Plaček graduated from the Institute of Chemical Technology in Prague in Analytical Chemistry and in Measurement Engineering in Chemical and Food Industry and received his Ph.D. degree from the Faculty of Pharmacy in Brno. He dealt with development and design of biosensors for electronic noses and tongues with consequent mathematical signal processing. For several years he worked in the R&D Division of the pharmaceutical company Zentiva (now a part of Sanofi group) where he developed the methods of capillary electrophoresis (CE) for separation of APIs and excipients and mass spectrometry (MS) as an analytical tool of identification and quantification of main components and impurities in mixtures (in combination GC-MS and LC-MS). At present Mr. Plaček works as a product specialist in organic analysis in Pragolab, a Czech representative of the world leader in scientific equipment Thermo Fisher Scientific. He is a co-author of a number of patents, scientific publications and conference contributions.

Selected publications

Rádl S.; Černý J.; Klecán O.; Stach J.; Plaček L.; Mandelová Z. A Synthesis of Licofelone Using Fenton´s Reagent. Tetrahedron Lett. 2008, 49 (36): 5316-5318.

Stach, J.; Havlíček, J.; Plaček, L.; Rádl, S. Synthesis of Some impurities and/or Degradation Products of Atorvastatin. Collect. Czech. Chem. Commun. 2008, 73 (2): 229-246. 

Havlíček, J.; Mandelová, Z.; Weisemann, R.; Střelec, I.; Plaček, L.; Rádl, S. Identification, Synthesis and Structural Determination of Some Impurities of Candesartan Cilexetil. Collect. Czech. Chem. Commun. 2009, 74 (2): 347-362. 

Rádl, S.; Blahovcová, M.; Plaček, L.; Pekárek, T.; Havlíček, J. Synthesis of Some Impurities and/or Degradation Products of Zaleplone. J. Heterocyclic Chem. 2010, 47 (1): 276-283.

Brychtová, K.; Opatřilová, R.; Raich, I.; Kalinowski, D.; Dvořáková, L.; Plaček, L.; Csőllei, J.; Richardson, D.R.; Jampílek, J. Investigating the Activity of 2-Substituted Alkyl-6-(2,5-dioxopyrrolidin-1-yl)hexanoates as Skin Penetration Enhancers. Bioorg. Med. Chem. 2010, 18 (24): 8556-8565.

Dohnal, J.; Plaček L. Electromigration Separation Methods. In: Modern Approaches to Pharmaceutical Analysis. Dohnal J.; Jampílek J.; Král V.; Řezáčová A. (Eds.) Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Prague, 2010, pp. 142-159. [ISBN 978‑80‑7305-085-6, CD-Edition: ISBN 978-80-7305-095-5]

Plaček L.; Řezáčová A. Hmotnostní spektrometrie. In: Modern Approaches to Pharmaceutical Analysis. (Dohnal J.; Jampílek J.; Král V.; Řezáčová A. (Eds.) Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Prague, 2010, pp. 314-346. [ISBN 978‑80‑7305-085-6, CD-Edition: ISBN 978-80-7305-095-5] 

Douša M.; Gibala P.; Havlíček J.; Plaček L.; Tkadlecová M.; Břicháč J. Drug-excipient compatibility testing – Identification and characterization of degradation products of phenylephrine in several pharmaceutical formulations against the common cold. J. Pharm. Biomed. Anal., 2011, 55 (1): 949-956.

Mrózek, L.; Dvořáková, L.; Mandelová, Z.; Rárová, L.; Řezáčová, A.; Plaček, L.; Opatřilová, R.; Dohnal, J.; Paleta, O.; Král, V.; Drašar, P.; Jampílek, J. Investigation of New Acyloxy Derivatives of Cholic Acid and Their Esters as Drug Absorption Modifiers. Steroids 2011, 76 (10-11): 1082-1097.

Brychtová, K.; Dvořáková, L.; Opatřilová, R.; Raich, I.; Káčerová, S.; Plaček, L.; Kalinowski, D.; Richardson, D.R.; Jampílek, J. Investigation of Substituted 6-Aminohexanoates as Skin Penetration Enhancers. Bioorg. Med. Chem. 2012, 20 (1): 86–95.